NAD+ 500

Description

NAD⁺ stands for Nicotinamide Adenine Dinucleotide — a coenzyme found in every living cell.

Key facts

• Role in the body:
  • Essential for converting nutrients into cellular energy (ATP) through metabolic pathways like the Krebs cycle and oxidative phosphorylation
  • Acts as an electron carrier, switching between NAD⁺ (oxidized form) and NADH (reduced form)
  • Serves as a substrate for enzymes involved in DNA repair, gene expression, and cell survival (such as sirtuins and PARPs)
• Natural presence: Found in all human cells, but levels decline with age
• Forms: NAD⁺ (oxidized) and NADH (reduced) — the two forms continuously cycle in energy metabolism

Functions

1. Energy metabolism – Helps turn carbohydrates, fats, and proteins into usable energy (ATP)
2. Cell repair – Provides fuel for DNA repair enzymes
3. Gene regulation – Activates sirtuins, which influence aging and stress resistance
4. Neuroprotection – Supports healthy brain function and may protect neurons

Supplement & therapy context

• NAD⁺ precursors like NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are used to boost NAD⁺ levels
• IV NAD⁺ therapy is promoted (though with mixed scientific support) for anti-aging, energy, and mental clarity
• Sports & recovery: Claimed to support endurance and recovery, but evidence is still limited

Reconstitution

1. Supplies needed
   • 500 mg NAD⁺ powder vial
   • Sterile water for injection (SWFI) or 0.9% sodium chloride (NaCl)
   • Alcohol swabs
   • Sterile syringe & needle
2. Steps
   • Wipe vial stopper with alcohol swab
   • Draw 5 mL sterile diluent into syringe
   • Slowly inject diluent into vial
   • Gently swirl until fully dissolved (avoid shaking hard — NAD⁺ is delicate)

Result: Final concentration = 100 mg/mL

NAD⁺ Powder in Vial (Lyophilized Form) Over Solution form

• Stability: Much more stable — can be stored for months (often 12–24 months) if kept in a cool, dark place
• Shelf life after reconstitution: Typically 5–7 days refrigerated (sometimes less, as NAD⁺ is delicate in solution)
• Preparation needed: Must be reconstituted with sterile water or 0.9% NaCl before injection or IV use

Administration – Example IV Infusion

• Step 1: Withdraw desired dose (e.g., 250 mg = 2.5 mL) from reconstituted vial
• Step 2: Dilute in 100–250 mL 0.9% NaCl for infusion
• Step 3: Infuse slowly over 30–90 minutes
• Step 4: Monitor for flushing, nausea, headache — slow the infusion rate if needed

Administration – Example IM Injection

• Typical IM dose: 100–200 mg (1–2 mL from reconstituted vial)
• Inject into large muscle (e.g., glute or thigh)
• Rotate injection sites to reduce irritation

Storage

• Store unopened vials in a cool, dark place
• Reconstituted solution: Refrigerate (2–8 °C) and use within 7 days for best stability