Description
Semax is a synthetic peptide developed in Russia in the 1980s–1990s.
It is officially classified as a nootropic / neuroprotective agent.
It is derived from ACTH(4-10) (a fragment of adrenocorticotropic hormone), but without hormonal effects.
Approved uses in Russia:
- cognitive impairment
- post-stroke rehabilitation
- anxiety and stress-related dysfunction
- ADHD-like symptoms
- neuroprotection
It is typically administered intranasally.
✅ How It Works (Conceptually)
Research (mostly Russian) suggests Semax may:
- increase BDNF expression (brain-derived neurotrophic factor)
- modulate dopamine and serotonin pathways
- improve attention and memory
- show mild anxiolytic effects
- reduce oxidative stress
These effects are neurological, not hormonal and not anabolic.
❓ Use in Athletes / Bodybuilders
✔ What is known:
Some athletes use Semax off-label for:
- faster CNS recovery
- focus and concentration (training, competitions)
- reduced mental fatigue
- improved mood during prep
There is no evidence that Semax increases muscle mass, strength, fat loss, or performance directly.
⚠ Important:
- It is not approved in Western countries for athletic performance.
- Studies on athletes are extremely limited.
- WADA (anti-doping agency) has unclear stance: Semax is not explicitly banned, but ACTH-related peptides fall under certain categories. Interpretations vary.
So:
Yes, some athletes use it, but science does not clearly support athletic benefits.
⚠ Side Effects (Reported / Possible)
Semax is considered relatively well-tolerated, but side effects reported in available data:
Mild / Common
- nasal irritation
- headache
- anxiety or overstimulation
- irritability
- insomnia (if taken late)
- increased heart rate (rare)
Less common
- mood swings
- elevated blood pressure in susceptible people
- fatigue “crash” after repeated high use
- nausea
Long-term safety is unknown.
There are no large Western trials confirming long-term effects.
⚠ Dosing (General, Non-medical Overview Only)
I cannot provide medical dosing or suggest use.
But the commonly discussed research protocols (from Russian clinical papers) use:
- 0.1–0.3 mg per dose, intranasally
- 1–2× per day
- cycles of 5–10 days, then a break
Some Western users mention up to 0.5–1 mg per day recreationally — but this is not supported by medical literature.







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