Androxal (Enclomiphene Citrate)

Description

Androxal is the brand name for enclomiphene citrate, a selective estrogen receptor modulator (SERM) designed to stimulate the body’s natural testosterone production. Unlike traditional testosterone replacement therapies (TRT), Androxal works by activating the pituitary gland to increase LH and FSH, which in turn signal the testes to produce testosterone.

Enclomiphene is the trans-isomer of clomiphene citrate (Clomid) and is believed to deliver a more targeted effect on hormone regulation with fewer off-target actions.

💪 Positive Effects

• Increases natural testosterone levels
  (without suppressing sperm production)
• Preserves fertility
  (ideal for men looking to maintain or restore reproductive function)
• Improves energy, mood, and libido
  (in men with low testosterone)
• Supports lean muscle mass and recovery
• Restores hormonal feedback loop
  (stimulates LH/FSH rather than replacing testosterone externally)

⚠️ Possible Side Effects

As a SERM, enclomiphene shares a similar side-effect profile with clomiphene:

• Headaches
• Nausea or gastrointestinal discomfort
• Mood changes or irritability
• Blurred vision (rare)
• Risk of increased estrogen levels in some users (leading to bloating, gynecomastia if unmanaged)
• Potential for thromboembolic events (very rare; monitor risk in predisposed individuals)

Regular monitoring of hormones, liver function, and lipid profile is recommended.

🏋️ Application in Sport & Fitness

In the athletic world, Androxal may be used off-label to:

• Restore natural testosterone levels after steroid cycles (PCT)
• Maintain testosterone and fertility during or after long-term AAS use
• Support performance, recovery, mood, and libido without introducing synthetic testosterone

❌ Important: Enclomiphene is a prohibited substance under WADA’s S4 category (Hormone and Metabolic Modulators). Use is not allowed in professional sports without a valid Therapeutic Use Exemption (TUE).

🔬 Compared to Clomiphene (Clomid)

Compared to clomiphene, enclomiphene (the active component in Androxal) offers a more focused and predictable hormonal effect. Clomiphene is a mix of two isomers—enclomiphene (trans) and zuclomiphene (cis)—with the latter believed to linger longer in the body and possibly contribute to unwanted estrogenic side effects or mood disturbances. By isolating just the enclomiphene isomer, Androxal avoids the mixed activity of clomiphene and delivers a cleaner stimulation of LH and FSH, leading to more consistent testosterone production. Users often report fewer side effects, better mood stability, and more reliable hormonal responses, making it a preferred alternative for those who didn’t tolerate clomiphene well.

📌 Summary

Androxal offers a modern, targeted approach to boosting natural testosterone while maintaining fertility and hormonal balance. It’s an ideal option for men who want to avoid the suppressive effects of TRT or who did not tolerate traditional clomiphene well.

However, it is currently not FDA-approved, and not legal in competitive sports. Use only under the supervision of a qualified healthcare provider.